Publications

2020

Pristner M., Warth B., Drug-Exposome Interactions: The Next Frontier in Precision Medicine, Trends in Pharmacological Sciences, 2020 Dec;41(12):994-1005. doi: 10.1016/j.tips.2020.09.012.

Aichinger G., Živná N., Varga E., Crudo F., Warth B., Marko D., Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins, Mycotoxin Research, 2020 Nov. doi: 10.1007/s12550-020-00405-9.

Xue J., Guijas C., Bento H. P., Warth B., Siuzdak G., METLIN MS2 molecular standards database: a broad chemical and biological resource, nature methods, Oct. 2020, DOI: 10.1038/s41592-020-0942-5

Braun D., Eiser M., Puntscher H., Marko D., Warth B., Natural Contaminants in Infant Food: The Case of Regulated and Emerging Mycotoxins, Food Control, Oct. 2020, DOI:10.1016/j.foodcont.2020.107676

Pereira F. C., Wasmund K., Cobankovic I., Jehmlich N., Herbold C. W., Soo Lee K., Sziranyi B., Vesely C., Decker T., Stocker R., Warth B., von Bergen M., Wagner M., Berry D., Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonizatio, Nature Communications, 2020 Oct 9;11(1):5104. doi: 10.1038/s41467-020-18928-1

Crudo F., Aichinger G., Mihajlovic J., Dellafiora L., Varga E., Puntscher H., Warth B., Dall'Asta C., Berry D., Marko D., Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro, Archives of Toxicology, 2020 Oct;94(10):3541-3552. doi: 10.1007/s00204-020-02831-1. 

Braun D., Schernhammer E., Marko D., Warth B., Longitudinal Assessment of Mycotoxin Co-Exposures in Exclusively Breastfed Infants, Environment International, 2020 Sept;142:105845. doi: 10.1016/j.envint.2020.105845. 

Zhang Y., Liu M., Peng B., Jia S., Koh D., Wang Y., Sheng Cheng H., Soon Tan N., Warth B., Chen D., Fang M., Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems Biological Understanding of Synergism between Tris(1,3-dichloro-2-propyl)phosphate and Triphenyl Phosphate, Environmental Science and Technology, Sept. 1, 2020, DOI: 10.1021/acs.est.0c02188

Dator R., Villalta P. W., Thomson N., Jensen J., Hatsukami D. K., Stepanov I., Warth B., Balbo S., Metabolomics Profiles of Smokers from Two Ethnic Groups with Differing Lung Cancer Risk, Chemical Research in Toxicology, Aug. 17, 2020, DOI: 10.1021/acs.chemrestox.0c00064

Ezekiel Ch.N., Abia W.A., Braun D., Sarkanj B., Ayeni K.I., Qyedele O., Michael-Chikezie E.C., Ezekiel V.C., Mark B., Ahuchaogu Ch.P., Krska R., Sulyok M., Turner P., Warth B., Comprehensive mycotoxin exposure biomonitoring in breastfed and non-exclusively breastfed Nigerian children, Preprint, June 2020, DOI: 10.1101/2020.05.28.20115055

Braun D., Ezekiel Ch. N., Marko D., Warth B., Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach, Frontiers in Chemistry, May 2020, DOI: 10.3389/fchem.2020.00423, eCollection2020

Flasch M., Bueschl Ch., Woelflingseder L., Schwartz-Zimmermann H.E., Adam G., Schuhmacher R., Marko D., Warth B. Stable isotope-assisted metabolomics for deciphering xenobiotic metabolism in mammalian cell culture, ACS Chemical Biology, 2020 Apr. 17, doi: 10.1021/acschembio.9b01016

Beisl J., Pahlke G., Abeln H., Ehling-Schulz M., Del Favero G., Varga E., Warth B., Sulyok M., Abia W., Ezekiel CN., Marko D., Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells, Archives of Toxicology, 2020 March doi: 10.1007/s00204-020-02658-w

Puntscher H., Marko D., Warth B., First determination of the highly genotoxic fungal contaminantaltertoxin II in a naturally infested apple sample, Emerging Contaminants, Volume 6, 2020, Pages 82-86, January 2020, doi.org/10.1016/j.emcon.2020.01.002

2019

Puntscher H., Aichinger G., Grabher S., Attakpah E., Krüger F., Tillmann K., Motschnig T., Hohenbichler J., Braun D., Plasenzotti R., Pahlke G., Höger H., Marko D., Warth B., Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats, Archives of Toxicology, 2019 Nov. doi: 10.1007/s00204-019-02575-7

Warth B. , Preindl K., Manser P., Wick P., Marko D., Buerki-Thurnherr T., Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta, Environmental Health Perspectives, 2019 Oct;127(10):107004. doi: 10.1289/EHP4860

Aichinger G., Krüger F., Puntscher H., Preindl K., Warth B., Marko D., Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro, Archives of Toxicology, 2019 Oct. doi: 10.1007/s00204-019-02545-z

Riva A., Kuzyk O., Forsberg E., Siuzdak G., Pfann C., Herbold C., Daims H., Loy A., Warth B., Berry D., A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome, Nature Communications, 2019 Sep 25;10(1):4366. doi: 10.1038/s41467-019-12413-0.

Preindl K., Braun D., Aichinger G., Sieri S., Fang M., Marko D., Warth B., A Generic Liquid Chromatography-Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrice, Analytical Chemistry, 2019 Sep.3. doi: 10.1021/acs.analchem.9b02446

Puntscher H., Cobankovic I., Marko D., Warth B., Quantitation of free and modified Alternaria mycotoxins in European food products by LC-MS/MS, Food Control, Aug. 2019, DOI:10.1016/j.foodcont.2019.03.019

Puntscher H., Marko D., Warth B., The Fate of Altertoxin II During Tomato Processing Steps at a Laboratory ScaleTable, frontiers in nutrition, 2019 Jun 13;6:92. doi: 10.3389/fnut.2019.00092

Ezekiel C.N., Sulyok M., Ogara I.M., Abia W.A., Warth B., Šarkanj B., Turner P.C., Krska R., Mycotoxins in uncooked and plate-ready household food from rural northern NigeriaAuthor links open overlay panel, Food and Chemical Toxicology, Volume 128, June 2019, Pages 171-179, doi.org/10.1016/j.fct.2019.04.002

Woelflingseder L., Warth B., Vierheilig I., Schwartz‑Zimmermann H., Hametner C., Nagl V., Novak B., Šarkanj B., Berthiller F., Adam G., Marko D., The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol, Archives of Toxicology, 2019 Jun;93(6):1729-1743. doi: 10.1007/s00204-019-02459-w

Puntscher H., Hankele S., Tillmann K., Attakpah E., Braun D., Kütt M-L., Del Favero G., Aichinger G., Pahlke G., Höger H., Marko D., Warth B., First insights into Alternaria multi-toxin in vivo metabolism, Toxicology Letters, 2019 Feb;301:168-178. doi: 10.1016/j.toxlet.2018.10.006

Warth B., Palermo A., Rattray N.J.W., Lee N.V., Zhu Z., Hoang L.T., Mazurek A., Dann S., VanArsdale T., Fantin V., Shields D., Siuzdak G., Johnson C.H., Palbociclib and fulvestrant act in synergy to modulatecentral carbon metabolism in breast cancer cells, Metabolites, 2019 Jan 2;9(1). pii: E7. doi: 10.3390/metabo9010007

 

2018

Mastanjević K., Šarkanj B., Warth B., Krska R., Sulyok M., Mastanjević K., Šantek B., Krstanović V., Fusarium culmorum multi-toxin screening in malting and brewing by-products, LWT, Volume 98, December 2018, Pages 642-645, doi.org/10.1016/j.lwt.2018.09.047

Braun D., Ezekiel C.N., Abia W.A., Wisgrill L., Degen G.H., Turner P.C., Marko D., Warth B., Monitoring early-life mycotoxin exposures via LC-MS/MS breast milk analysis, Analytical Chemistry, 2018 Dec 18;90(24):14569-14577. doi: 10.1021/acs.analchem.8b04576

Woelflingseder L., Del Favero G., Blažević T., Heiss E.H., Haider M., Warth B., Adam G., Marko D., Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells, Toxicology Letters, 2018 Dec 15;299:104-117. doi: 10.1016/j.toxlet.2018.09.007

Del Favero G., Woelflingseder L., Braun D., Puntscher H., Kütt M-L., Dellafiora L., Warth B., Pahlke G., Dall'Asta C., Adam G., Marko D., Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates, Toxicology Letters, 2018 Oct 1;295:424-437. doi: 10.1016/j.toxlet.2018.07.007

Šarkanj B., Ezekiel CN., Turner PC., Abia WA., Rychlik M., Krska R., Sulyok M., Warth B., Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers, Analytica Chimica Acta, 2018 Aug 17;1019:84-92. doi: 10.1016/j.aca.2018.02.036

Palermo A., Forsberg E.M., Warth B., Aisporna A.E., Billings E., Kuang E., Benton H.P., Berry D., Siuzdak G., Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry, ACS Nano, 2018 Jul 24;12(7):6938-6948. doi: 10.1021/acsnano.8b02376.

Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B., Siuzdak G., Autonomous Multimodal Metabolomics Data Integration for Comprehensive Pathway Analysis and Systems Biology, Analytical Chemistry, 2018 Jul 17;90(14):8396-8403. doi: 10.1021/acs.analchem.8b00875.

Puntscher H., Kütt M-L., Skrinjar P., Mikula H., Podlech J., Fröhlich J., Marko D., Warth B., Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins, Analytical and Bioanalytical Chemistry, 2018 Jul;410(18):4481-4494. doi: 10.1007/s00216-018-1105-8

Mastanjević K., Šarkanj B., Krska R., Sulyok M., Warth B., Mastanjević K., Šantek B., Krstanović V., From malt to wheat beer: A comprehensive multi-toxin screening, transfer assessment and its influence on basic fermentation parameters, Food Chemistry, Volume 254, 15 July 2018, Pages 115-121, doi.org/10.1016/j.foodchem.2018.02.005

Dellafiora L., Warth B., Schmidt V., Del Favero G., Mikula H., Fröhlich J., Marko D. An integrated in silico/in vitro approach to assess the xenoestrogenic potential of  Alternaria mycotoxins and metabolites, Food Chemistry, 2018 May 15;248:253-261. doi: 10.1016/j.foodchem.2017.12.013.

Guijas C., Montenegro-Burke J.R., Warth B., Spiler M.E., Siuzdak G., Metabolomics activity screening for identifying metabolites that modulate phenotype, Nature Biotechnology, 2018 Apr 5; 36(4):316-320. doi: 10.1038/nbt.4101

Forsberg E.M., Huan T., Rinehart D., Benton H.P., Warth B., Hilmers B., Siuzdak G., Data processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online, Nature Protocols, 2018 Apr;13(4):633-651. doi: 10.1038/nprot.2017.151.

Okeke C.A., Ezekiel C.N., Sulyok M., Ogunremi O.R., Ezeamagu C.O., Šarkanj B., Warth B., Krska R., Traditional processing impacts mycotoxin levels and nutritional value of ogi - A maize-based complementary food, Food Control, Volume 86, April 2018, Pages 224-233, doi.org/10.1016/j.foodcont.2017.11.021

Guijas C., Montenegro-Burke J.R., Domingo-Almenara X., Palermo A., Warth B., Hermann G., Koellensperger G, Huan T, Uritboonthai W, Aisporna AE, Wolan DW, Spilker ME, Benton HP, Siuzdak G., METLIN: A Technology Platform for Identifying Knowns and Unknowns, Analytical Chemistry, 2018 Mar 6;90(5):3156-3164. doi: 10.1021/acs.analchem.7b04424

Warth B., Raffeiner P., Granados A., Huan T., Fang M., Forsberg E.M., Benton H.P., Goeth L., Johnson Ch., Siuzdak G., Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy, Cell Chemical Biology, 2018 Mar 15;25(3):291-300.e3. doi: 10.1016/j.chembiol.2017.12.010

Jarolim K., Wolters K., Woeflingseder L., Pahlke G., Beisl J., Puntscher H., Braun D., Sulyok M., Warth B., Marko D., The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells, Toxicology Letters, 2018 Mar 1;284:170-183. doi: 10.1016/j.toxlet.2017.12.008

Aichinger G., Puntscher H., Beisl J., Kütt M.L., Warth B., Marko D., Delphinidin protects colon carcinoma cells against the genotoxic effects of the mycotoxin altertoxin II, Toxicology Letters, 2018 Mar 1;284:136-142. doi: 10.1016/j.toxlet.2017.12.002

Griesser M., Martinez SC., Eitle MW., Warth B., Andre CM., Schuhmacher R., Forneck A., The ripening disorder berry shrivel affects anthocyanin biosynthesis and sugar metabolism in Zweigelt grape berries, Planta, 2018 Feb;247(2):471-481. doi: 10.1007/s00425-017-2795-4

 

2017

Warth B., Spangler S., Fang M., et al. Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing, Analytical Chemistry, 2017 Nov 7;89(21):11505-11513. doi: 10.1021/acs.analchem.7b02759.

Johnson C.H., Santidrian A.F., LeBoeuf S.E., Kurczy M.E., Rattray N.J.W., Rattray Z., Warth B., Ritland M., Hoang L.T., Loriot C., Higa J., Hansen J.E., Felding B.H., Siuzdak G., Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids, Cancer & Metabolism, 2017 Oct 31;5:9. doi: 10.1186/s40170-017-0171-2. eCollection 2017

Adedeji B.S., Ezeokoli O.T., Ezekiel C.N., Obadina A.O., Somorin Y.M., Sulyok M., Adeleke R.A., Warth B., Nwangburuka C.C., Omemu A.M., Oyewole O.B., Krska R., Bacterial species and mycotoxin contamination associated with locust bean, melon and their fermented products in south-western Nigeria, International Journal of Food Microbiology, 2017 Oct 3;258:73-80. doi: 10.1016/j.ijfoodmicro.2017.07.014. 

Abia W.A., Warth B., Ezekie C.N.l, Sarkanj B., Turner P.C., Marko D., Krska R., Sulyok M., Uncommon toxic microbial metabolite patterns in traditionally home-processed maize dish (fufu) consumed in rural Cameroon; Food and Chemical Toxicology, Volume 107, Part A, September 2017, Pages 10-19, doi.org/10.1016/j.fct.2017.06.011

Oyedele O.A., Ezekiel C.N., Sulyok M., Adetunji M.C., Warth B., Atanda O.O., Krska R., Mycotoxin risk assessment for consumers of groundnut in domestic markets in Nigeria, International Journal of Food Microbiology, 2017 Jun 19;251:24-32. doi: 10.1016/j.ijfoodmicro.2017.03.020

Warth B., Levin N., Rinehart D., et al., Metabolizing Data in the Cloud, Trends in Biotechnology, June 2017, DOI: dx.doi.org/10.1016/j.tibtech.2016.12.010

Ogara I.M., Zarafi A.B., Alabi O., Banwo O., Ezekiel C.N., Warth B., Sulyok M., Krska R., Mycotoxin patterns in ear rot infected maize: A comprehensive case study in Nigeria, Food Control, Vol. 73, Part B, March 2017, Pages 1159-1168, Doi: 10.1016/j.foodcont.2016.10.034

Tiessen C., Ellmer D., Mikula H., Pahlke G., Warth B., Gehrke H., Zimmermann K., Heiss E., Fröhlich J., Marko D., Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells, Archives of Toxicology, 2017 Mar;91(3):1213-1226. doi: 10.1007/s00204-016-1801-0.

Vejdovszky K., Schmidt V., Warth B., Marko D., Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro, Molecular Nutrition and Food Research, March 2017. doi: 10.1002/mnfr.201600526.

Vejdovszky K., Hahn K., Braun D., Warth B., Marko D., Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro, Archives of Toxicology, March 2017, DOI 10.1007/s00204-016-1795-7

Egbontan AO., Afolabi CG., Kehinde IA., Enikuomehin OA., Ezekiel CN., Sulyok M., Warth B., Krska R., A mini-survey of moulds and mycotoxins in locally grown and imported wheat grains in Nigeria. Mycotoxin Research, Feb. 2017, 33(1): 59.64. Doi: 10.1007/s12550-016-0264-8

Montenegro-Burke JR., Aisporna AE., Benton HP., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe BT., Ivanisevic J., Wolan DW., Teyton L., Lairson L., Siuzdak G., Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes, Analytical Chemistry, 2017 Jan 17;89(2):1254-1259. doi: 10.1021/acs.analchem.6b03890. 

 

2016

Warth B., Del Favero G., Wiesenberger G., Puntscher H., Woelflingseder L., Fruhmann P., Sarkanj B., Krska R., Schuhmacher R., Adam G., Marko D., Identification of a novel humen deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells, Scientific Reports, 2016 Sep, 23; 6:33854. doi: 10.1038/srep33854

Boedi S., Berger H., Sieber Ch., Muensterkoetter M., Maloku I., Warth B., Sulyok M., Lemmens M., Schuhmacher R., Gueldener U., Strauss J., Comparison of Fusarium graminearum Transcriptomes on Living or Dead Wheat Differentiates Substrate-Responsive and Defense-Responsive Genes, frontiers in Microbiology, July 26th, 2016, doi.org/10.3389/fmicb.2016.01113

Warth B., Braun D., Ezekiel Ch.N., Turner P.C., Degen G.H., Marko D., Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives, Chemical Research in Toxicology, July 18th 2016, doi: 10.1021/acs.chemrestox.6b00125

Vejdovszky K., Warth B., Sulyok M., Marko D., Non-synergistic cytotoxic effects of Fusarium and Alternaria toxin combinations in Caco-2 cells. Toxicology Letters, Jan.2016. doi: 10.1016/j.toxlet.2015.10.024

 

2015

Schmeitzl C., Varga E., Warth B., Kugler K.G., Malachova A., Michlmayr H., Wiesenberger G., Mayer K.F.X., Mewes H-W., Krska R., Schuhmacher R., Berthiller F., Adam G., Identifcation and characterization of Carboxylesterases from Brachyppodium distachyon Deacetylating Trichothecene Mycotoxins, Toxins, 2015 Dec 25;8(1). pii: E6. doi: 10.3390/toxins8010006.

Warth B., Siegwart G., Lemmens M., Krska R., Adam G., Schumacher R., Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for the quanitfication of UDP-glucose, UDP-glucuronic acid, deoxynivalenol and its glucoside: In-house validation and application to wheat, Journal of Chromatography A, Dez. 2015, doi: 10.1016/j.chroma.2015.10.070

Nussbaumer T., Warth B., Sharma S., Ametz C., Bueschl C., Parich A., Pfeifer M., Siegwart G., Steiner B., Lemmens M., Schuhmacher R., Buerstmayr H., Mayer K. FX., Kugler K, Schweiger W., Joint Transcriptomic and Metabolomic Analyses Reveal Changes in the Primary Metabolism and Imbalances in the Subgenome Orchestration in the Bread Wheat Molecular Response to Fusarium Graminearum. G3 Genes / Genomes / Genetics, Oct. 2015, doi: 10.1534/g3.115.021550

Schmeitzl C., Warth B., Fruhmann Ph., Michlmayr H., Malachova A., Berthiller F., Schumacher R., Krska R., Adam G., The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-0-Glucoside, 15-Acetyl-DON-3-0-Glucoside and 15-Acetyl-DON-3-Sulfate. Toxins, Aug. 2015, doi: 10.3390/toxins7083112

Warth B., Parich A., Bueschl C., et al. GC-MS based targeted metabolic profiling identifies changes in the wheat metabolome following deoxynivalenol treatment, Metabolomics, June 2015, Volume 11, Issue 3, pp 722–738, DOI: 10.1007/s11306-014-0731-1

Warth B., Fruhmann P., Wiesenberger G., Kluger B., Sarkanj B., Lemmens M., Hametner C., Fröhlich J., Adam G., Krska R., Schuhmacher R,. Deoxynivalenol-sulfates: identification and quantification of novel conjugated (masked) mycotoxins in wheat, Analytical and Bioanalytical Chemistry, Feb. 2015

 

2010-2014

Warth B., Petchkongkaew A., Sulyok M., Krska R., Utilizing an LC-MS/MS based multi-biomarker approach to assess the mycotoxin exposure in the Bangkok metropolitan area and surrounding provinces, Food Additives and Contaminants, Dec. 2014

Šarkanj B., Warth B., Uhlig S., et al. Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia, Food and Chemical Toxicology, Dec. 2013

Warth B., Sulyok M., Krska R., LC-MS/MS based multi-biomarker approaches for the assessment of human exposure to mycotoxins, Analytical and Bioanalytical Chemistry, July 2013

Warth B., Sulyok M., Berthiller F., et al. New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone, Toxicology Letters, June 2013

Warth B., Parich A., Atehnkeng J., et al. Quantitation of mycotoxins in food and feed from Burkina Faso and Mozambique using a modern LC-MS/MS multitoxin method, Journal of Agricultural and Food Chemistry, Sept. 2012

Warth B., Sulyok M., Fruhmann., et al. Development and validation of a rapid multi-biomarker LC-MS/MS method to assess human exposure to mycotoxins, Rapid Communications in Mass Spectrometry, July 2012

Warth B., Sulyok M., Fruhmann P., et al. Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method, Toxicology Letters, May 2012

Warth B., Sulyok M., Berthiller F., et al. Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol, Analytical and Bioanalytical Chemistry, July 2011

Warth B., Rajkai G., Mandenius C-F., Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein. Journal of Biotechnolog, May 2010