- MASTER THESIS "Optimization of sample preparation workflows forhigh-throughput exposomics"
This thesis in the field of bioanalytical chemistry is dedicated to the development andoptimization of a workflow for high throughput LC-MS-based sample preparation inexposomic and metabolomic research.
Exposure to environmental chemicals plays a critical role in the onset of diseases. Exposomeresearch aims to monitor relevant exogenous chemicals in human samples using a holisticapproach that can associate exposure levels with health outcomes. Due to its high sensitivityand selectivity, LC-MS is the key technology used to characterize these associations. To enablethe high-throughput capacity required, optimized high-throughput sample preparationworkflows are a key element that will be tested within this thesis.
For more information check out: here
HIRING NOW! | ERC- and Exposome Austria funded position open!
Within our new projects, we are looking for skilled technician. Apply via email now and become part of a dynamic and collaborative team investigating the impact of toxicants on human health:
Technician for Exposome Austria infrastructure (Lab management, MS library curation, routine measurements – German required) Sounds as exactly for you? Read the posting description here.
- July 2023 | Happy to welcome our collaborator and visiting scientist Julia Kuligowski from La Fe, the Health Research Institute Hospital in Valencia (IIS La Fe). Julia will be supporting us during the summer working on early-life exposure assessment. Welcome!
- June 30, 2023 | Interview for Rudolphina
(for our German-speaking audience)
Excited to share the latest insights from the interview with Professor Benedikt Warth in the University of Vienna's magazine, Rudolphina. The summarizing
article "Schadstoffe gehen durch den Magen" (Toxins pass through the stomach) introduces one of the "hot topics" in today's science - exposome. Besides the current ERC Project EXPOMET and other topics, it also reveals:
- What are the primary triggers of chronic diseases.
- How exposome research contributes to unraveling the causes of breast cancer.
- Why we should be shifting from the repair to personalized prevention medicine.
#ExposomeResearch #ExposomeAustria #ERC #Expomet
- June 2023 ASMS 2023 | Exposome Austria at Mass Spec conference in Houston
Early this month, three members of the Exposome Austria team at the University of Vienna - Benedikt Warth, Max. L. Feuerstein and Vinicius V. Hernandes - traveled overseas to Houston, Texas, to present current exposomics research at the 71st conference of the American Society for Mass Spectrometry (ASMS). Much interest in our new methods and results!
While Benedikt contributed as a presider of one the exposomics interest group workshops and gave a talk Exposomic approaches for next-generation human biomonitoring, our team has also a chance to present their posters on the following topics:
- Integrating veterinary drugs and pesticides into a targeted LC-MS/MS exposome-scale
biomonitoring (Md Zakir Hossain et.al., presented by Benedikt Warth)
- Multi-class assessment of chemical exposure in dried blood spots: a pilot study (Vinicius V.
Hernandes et. al.)
- HRMS-based Exposomics for Evaluating Embryonic Exposure and Cross-Placental Transfer of
Xenobiotics (Max L. Feuerstein et.al.)
#ASMSConference2023 #ExposomeAustria #ScientificResearch #EIRENE
- October 2022 We are growing fast! Welcome to our two new PostDocs Jesse Peach and Max Feuerstein! We are very much looking forward to working together with them in the next few years.
- August 2022 Congratulations to Yasmin Fareed who performed her master thesis under the supervision of Benedikt Warth and successfully defended it on Aug. 02.
- May 2022 On May 31st, the Exposome Austria Launch Event took place in the presence of high-ranking representatives of universities and research institutions, the Ministry of Science and Climate Change as well as colleagues and guests in the Small Ceremonial Hall of the University of Vienna.
For more information (in German) check out the faculty website:
https://chemie.univie.ac.at/wissensaustausch/veranstaltungen/exposome-at-2022/
Here you find the recording of the whole event:
https://www.youtube.com/watch?v=hmFBZzK3Fhw
- March 2022 On May 31 the Exposome Austria research infrastructure will be officially launched via an opening event at the University of Vienna. This is a public event and all interested stakeholders are most welcome! Please register early on: https://veranstaltung.univie.ac.at/exposome
- January 2022 We are looking for a motivated student to perform a master thesis in polyphenol analytics in our group. More info here.
- January 2022 New pre-print out. Great collaboration with colleagues from the Medical University of Vienna. The future of exposome-scale human biomonitoring? https://chemrxiv.org/engage/chemrxiv/article-details/61dd577681f3fee94fa326f6
- November 2021 Congratulations to Mira for the "New Ideas Award" of the DoSChem (Doctoral School of Chemistry) for the project “Investigating environmental exposures to infants using a multi-omics approach”. We are excited for the upcoming innovative experiments with Martin Schaier from the Koellensperber Lab! See here for more information!
- October 2021 Congratulations to Benedikt for winning a prestigious "Förderpreis" of the City of Vienna in the category "mathematics, informatics, natural sciences and technology"! Check out here
- September 2021 Longterm team-member Dominik left for starting a great position in industry. He joined our lab in 2015 as a PhD student, finished his thesis "Innovative LC-MS/MS breast milk biomonioring: Assessing infant's and mother's exposure to mycotoxins" in 2020 and stayed another successful year as PostDoc in the team. For sure, he will be missed! We wish him all the best for his new job and life in Upper Austria!
- May 2021 Congratulations to Benedikt for winning the prestigious Brigitte Gedek-Science Award of the Society of Mycotoxin Research; the highest prize globally in the field of natural toxins: http://www.mykotoxin.de/docs/public/tmplt_article.asp?CntID=51
- May 2021 Welcome to visiting scientist and Ernst Mach fellow Kola Ayeni from Nigeria who´s joining the team of Benedikt Warth for 9 months.
- March 2021 On Tuesday, March 16, the wordwide first journal in the field of exposomics was launched by Oxford University Press. Among the eight Associate Editors is also Benedikt Warth of the Department of Food Chemistry and Toxicology. For more information click here.
- March 2021 Online Workshop on April 28, 2021: The Metabolome Meets the Exposome - All Participants are welcome to register for free: http://www.nordicmetsoc.org/MetExposome2021.html .
- January 2021 On January 27 Benedikt Warth is guest speaker in a virtual research seminar hosted by the Social Exposome Cluster at the University of British Columbia in Vancouver, Canada. Check out this link to find out about how to join the Zoom meeting.
- December 2020 Congratulations to the next graduate of the Food Chemistry master programme: Sadia Achmad successfully defended her master thesis entitled "Study on plant metabolites of prenylated flavanoids in fruits". She performed it at the Technical University of Munich (TUM) under the supervision of Michael Rychlik, Lance Buckett and Benedikt Warth.
- December 2020 Congratulations to Benedikt Warth for receiving the "Feigl Preis" of the Austrian Society of Analytical Chemistry (ASAC)!
- December 2020 Check out Manuel´s review on "Drug-Exposome Interactions" in Trends in Pharmacological Sciences: Drug-Exposome Interactions: The Next Frontier in Precision Medicine
- November 2020 Congrats to Dominik Braun for winning the ASAC JunganalytikerInnen-Preis 2020 together with Sebastian Guntner from the JKU. The award was sponsered by "FTC-Forensisch-Toxikologisches Labor BgmbH", Vienna. The award ceremony took place online.
- November 2020 Congratulations to Thomas Jamnik for successfully defending his master theses!
- October 2020 Very glad being involved in this great METLIN initiative published in Nature Methods ... now facilitating exposomics research with many toxicants, contaminants, drugs, and xenobiotics (i.e. the #exposome)
- September 2020 Very warm welcome to our new Erasmus Exchange MSc Student Yasmin Borutzki!
- September 2020 Welcome back, Dominik Braun, now in a PostDoc-position!
- September 2020 Very warm welcome to our new PhD Student Magdalena Krausova!
- August 2020 Grateful for the chance to contribute to this Nature Methods paper form the September issue!
- June 2020 Congrats to Dominik Braun for successfully defending his PhD-thesis "Innovative LC-MS/MS breast milk biomonioring: Assessing infant's and mother's exposure to mycotoxin." The thesis was supervised by Prof. Marko and Prof. Warth.
- June 2020 Congratulations to Patrick Windisch for successfully defending his master thesis. He was supervised by Benedikt Warth and Dominik Braun.
- April 2020: Newest pre-prints for a good reading experience during home office times:
1. https://www.biorxiv.org/content/10.1101/2020.03.27.011072v1 (Longitudinal assessment of mycotoxin co-exposures in exclusively breastfed infants): Wonderful new cooperation with MedUni Vienna and Harvard Medical School
2. https://chemrxiv.org/articles/Exposure_to_Mycotoxin-Mixtures_via_Breast_Milk_An_Ultra-Sensitive_LC-MS_MS_Biomonitoring_Approach/11763555/1: Most sensitive method for mycotoxins in breast milk: Great and long-lasting cooperation with Babcock University, Nigeria
- March 2020 Congratulations to Mira Flasch to her first first-author article: Stable isotope-assisted metabolomics for deciphering xenobiotic metabolism in mammalian cell culture
- March 2020 Very warm welcome to our new PhD Student Ian Oesterle!
- January 2020: Very warm welcome to our new PhD Student Manuel Pristner!
- November 2019 Graduation: We congratulate Vincent Lüttig for successfully graduating from the master programme Food Chemistry! He performed his master thesis about the effect of Alternaria toxins on the metabolome of rats by LC-HRMS under the supervision of Benedikt Warth.
- November 2019 ORF Interview: Saturday, Nov. 23, 2019, another interview of Benedikt Warth about the state of the art of the research about the exposome, to be seen at the ORF TVTHEK (in German, starting at 12:22).
- November 2019 Ö1 Live Interview: On Monday, Nov. 25, 2019 Benedikt Warth was guest at the radiostation Ö1, giving a live interview at the series "Punkt eins" about the exposome: "Das Ich und seine unsichtbare, dynamische Wolke" (in German).
- November 2019: Plenary lecture of Assoc. Prof. Benedikt Warth and vivid discussion with Prof. Doris Marko at the 6. event "Umwelt in Gespräch" on Tuesday, Nov. 5, 2019. "Umwelt in Gespräch" is a series of public discussions organised by the Environmental Sciences Research Network of the University of Vienna in cooperation with the Natural History Museum Vienna.
You can find a review at the Online Standard and the lecture of Prof. Warth on youtube.
Skokanitsch Fotografie www.skokanitsch.com
Skokanitsch Fotografie www.skokanitsch.com
- October 2019: New paper, new insights: Placenta transit of an environmental estrogen
Press release:
Researchers show path of zearalenone through the womb using new technology
Paper:
Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta
Focus Online:
Erhöhtes Krebsrisiko: Warum Babys schon im Mutterleib unter Umwelthormonen leiden
- September 2019: New paper in the open access magazin "Nature Communications": Riva A., Kuzyk O., Forsberg E., Siuzdak G., Pfann C., Herbold C., Daims H., Loy A., Warth B., Berry D., A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome
- September 2019: We are hiring a PhD student to conduct exciting research at the interface of exposome, metabolome, and microbiome research.
Application and further details:
https://univis.univie.ac.at/ausschreibungstellensuche/flow/bew_ausschreibung-flow?_flowExecutionKey=_cF563EEDB-107A-9C73-85EA-D9EAE999DB81_k5DEF8B15-2CA9-56FB-9900-415A86AC57E2
- Aug. 2019: We congratulate our former PhD student Hannes Puntscher to his successfull defensio and graduation and wish him all the best for his future.
- Aug. 2019: New paper presenting a novel approach for multi-class xenoestrogen biomonitoring accepted by Analytical Chemistry: pubs.acs.org/doi/10.1021/acs.analchem.9b02446
- July 2019: Honoured to present our most recent research projects at the Yale School of Public Health and at a Gordon Research Conference. Great discussions with old and new friends and collaborators!
- July 2019: We welcome our new Master Student Patrick Windisch and Erasmus Intern Ipek Savas!
- May 2019: Very cool paper from our colleague Lydia: How a ‘non-toxic’ metabolite can suppress glucuronidation (i.e. detoxification) of a food toxin: https://link.springer.com/article/10.1007/s00204-019-02459-w
- Mar. 2019: New paper responding to the 2016 EFSA scientific report by providing comprehensive exposure/occurrence data of the emerging Alternaria mycotoxins: https://doi.org/10.1016/j.foodcont.2019.03.019
- Mar. 2019: We welcome our new Bachelor Student Natascha Stoirer!
- Feb. 2019: Best Poster Award: Congratulations to Dominik Braun who won the "Best Poster Award" at the MassSpec-Forum 2019 in Vienna, Austria
- Jan. 2019: Great to see that our current paper on combined breast cancer therapy was accepted and selected to be the cover paper of the January issue of Metabolites.
- Jan. 2019: We welcome our Research Fellow from India Kausar Ansari!
- Dec. 2018: Dominik’s first paper was accepted by Analytical Chemistry. Congrats! Open access via UNIVIE’s support.
- Oct. 2018: We welcome our new Bachelor Student Maximilian Eiser and our new Master Student Vincent Lüttig!
- Sept. 2018: Our research on untargeted mass spec screening in foodstuff was covered in a radio interview: download
- May 2018: Congratulations to our Master Student Karin Preindl who won the "Best Presentation Award" at the JunganalytikerInnen Forum 2018! Great appreciation of three months of hard work.
- May 2018: We welcome our new PhD Student Mira Flasch!
- Mar. 2018: Exciting to see that our work on xenoestrogens was selected as cover story in the Cell Chemical Biology March 2018 issue: Cell Chemical Biology
Media Platform of the University of Vienna
APA Report
Free access to the full article for 50 days
- Feb. 2018: We welcome Karin Preindl as a new master student in our team. She will focus on endocrine active chemicals related to food.
- Jan. 2018: Exciting new insights on the effect of xenoestrogens on breast cancer therapy:
Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy
Press release and related information:
http://www.scripps.edu/news/press/2018/20170111siuzdak.html
https://medicalresearch.com/cancer-_-oncology/dietary-estrogens-have-potential-to-affect-cancer-outcomes/39350/
- Dec. 2017: Our collaborative paper on the toxic effects of aurofusarin is out. Congrats Kathi!
The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells
- Dec. 2017: Paper on estrogenic effects of Alternaria toxins was accepted by Food Chemistry. Thanks for the nice collaboration to Luca and all other co-authors!
An integrated in silico/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites
- Nov. 2017: New paper on global exposomics technology and artificial intelligence for metabolomics acceleration published in Analytical Chemistry:
Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing
- Autumn 2017: New web page launched